Print friendly version
Adult-onset vitelliform macular dystrophy
Other Names for this Disease
- Adult-onset foveomacular vitelliform dystrophy
- Foveomacular dystrophy, adult-onset, with choroidal neovascularization
- Foveomacular dystrophy, adult-onset; AOFMD
- Macular dystrophy, vitelliform, adult-onset
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 Signs and symptoms usually begin between ages 30 and 50 and include blurred and/or distorted vision, which can progress to central vision loss over time. It is caused by mutations in the PRPH2 or BEST1 genes; other unidentified genes may cause AVMD as well. It is thought to be inherited in an autosomal dominant manner, although not all individuals who inherit the mutated gene develop symptoms.Adult-onset vitelliform macular dystrophy (AVMD) is a genetic eye disorder that can cause progressive vision loss. AVMD affects an area of the retina called the macula, which is responsible for sharp central vision. The condition causes a fatty yellow pigment to accumulate in cells underlying the macula, eventually damaging the cells.
Last updated: 10/3/2013
- Vitelliform macular dystrophy. Genetics Home Reference. October 2008; http://ghr.nlm.nih.gov/condition/vitelliform-macular-dystrophy. Accessed 9/4/2012.
- Cassandra L. Kniffin. MACULAR DYSTROPHY, VITELLIFORM, ADULT-ONSET. OMIM. December 13, 2006; http://omim.org/entry/608161. Accessed 9/4/2012.
- Do P, Ferrucci . Adult-onset foveomacular vitelliform dystrophy. Optometry. April 2006; 77(4):156-166.
- Genetics Home Reference (GHR) contains information on Adult-onset vitelliform macular dystrophy. This website is maintained by the National Library of Medicine.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Adult-onset vitelliform macular dystrophy. Click on the link to go to OMIM and review these resources.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adult-onset vitelliform macular dystrophy. Click on the link to view a sample search on this topic.