Print friendly version
Adult neuronal ceroid lipofuscinosis
Other Names for this Disease
- Adult NCL
- Kuf's disease
- Neuronal ceroid lipofuscinosis 4
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
 There are two forms of adult neuronal ceroid lipofuscinosis. Type A is caused by mutations in the CLN6 gene and is inherited in an autosomal recessive pattern. Type B can be caused by mutations in the DNAJC5 gene and is inherited in an autosomal dominant pattern. Treatment options for adult neuronal ceroid lipofuscinosis are limited to therapies that can help relieve some of the symptoms.Adult neuronal ceroid lipofuscinosis is a disorder of the nervous system. Symptoms usually begin before age 40 and include movement disorders, seizures, dementia, and speech problems. Unlike other forms of neuronal ceroid lipofuscinosis, the adult form does not cause blindness.
Last updated: 11/29/2012
- Kufs disease. Genetics Home Reference. September 2010; http://ghr.nlm.nih.gov/condition/kufs-disease. Accessed 11/29/2012.
- CEROID LIPOFUSCINOSIS, NEURONAL, 4A, AUTOSOMAL RECESSIVE. OMIM. May 17, 2011; http://omim.org/entry/204300. Accessed 11/29/2012.
- CEROID LIPOFUSCINOSIS, NEURONAL, 4B, AUTOSOMAL DOMINANT. OMIM. October 21, 2011; http://omim.org/entry/162350. Accessed 11/29/2012.
- Mole SE, Williams RE. Neuronal Ceroid-Lipofuscinoses. GeneReviews. March 2, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1428/. Accessed 11/29/2012.
- Genetics Home Reference (GHR) contains information on Adult neuronal ceroid lipofuscinosis. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
In Depth Information
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Adult neuronal ceroid lipofuscinosis. Click on the link to view a sample search on this topic.