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Adult neuronal ceroid lipofuscinosis


Other Names for this Disease

  • Adult NCL
  • ANCL
  • Kuf's disease
  • Neuronal ceroid lipofuscinosis 4
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Adult neuronal ceroid lipofuscinosis is a disorder of the nervous system. Symptoms usually begin before age 40 and include movement disorders, seizures, dementia, and speech problems. Unlike other forms of neuronal ceroid lipofuscinosis, the adult form does not cause blindness.[1] There are two forms of adult neuronal ceroid lipofuscinosis. Type A is caused by mutations in the CLN6 gene and is inherited in an autosomal recessive pattern.[2] Type B can be caused by mutations in the DNAJC5 gene and is inherited in an autosomal dominant pattern.[3] Treatment options for adult neuronal ceroid lipofuscinosis are limited to therapies that can help relieve some of the symptoms.[4]
Last updated: 11/29/2012

References

  1. Kufs disease. Genetics Home Reference. September 2010; http://ghr.nlm.nih.gov/condition/kufs-disease. Accessed 11/29/2012.
  2. CEROID LIPOFUSCINOSIS, NEURONAL, 4A, AUTOSOMAL RECESSIVE. OMIM. May 17, 2011; http://omim.org/entry/204300. Accessed 11/29/2012.
  3. CEROID LIPOFUSCINOSIS, NEURONAL, 4B, AUTOSOMAL DOMINANT. OMIM. October 21, 2011; http://omim.org/entry/162350. Accessed 11/29/2012.
  4. Mole SE, Williams RE. Neuronal Ceroid-Lipofuscinoses. GeneReviews. March 2, 2010; http://www.ncbi.nlm.nih.gov/books/NBK1428/. Accessed 11/29/2012.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Adult neuronal ceroid lipofuscinosis. This website is maintained by the National Library of Medicine.
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Other Names for this Disease
  • Adult NCL
  • ANCL
  • Kuf's disease
  • Neuronal ceroid lipofuscinosis 4
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.