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Genetic and Rare Diseases Information Center (GARD)

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Autoimmune polyglandular syndrome type 3


Other Names for this Disease
  • APS3
  • Autoimmune polyendocrine syndrome type 3
  • PAS3
  • Polyglandular autoimmune syndrome type 3
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Overview


Autoimmune polyglandular syndrome (APS) type 3 is an autoimmune condition that affects the body's endocrine glands. The syndrome, which typically affects women during middle age, results from failure of the glands to produce their hormones. This condition is characterized by autoimmune thyroiditis along with another organ-specific autoimmune disease.[1][2][3] The other autoimmune diseases may include diabetes mellitus, pernicious anemia, vitiligo, alopecia, myasthenia gravis, and Sjogren's syndrome.[2] The adrenal cortex (the outer layer of the adrenal gland) is not involved.[1][2][3] There are three types of autoimmune polyglandular syndrome type 3:[1][2] 
Last updated: 1/15/2013

References

  1. Aung K. Type III Polyglandular Autoimmune Syndrome. Medscape Reference. January 2012; http://emedicine.medscape.com/article/124398-overview. Accessed 1/15/2013.
  2. Cihakova D. Polyglandular Autoimmune syndrome Type 3 (PAS 3) . Johns Hopkins Medical Institutions: Autoimmune Disease Research Center. September 2001; http://autoimmune.pathology.jhmi.edu/diseases.cfm?systemID=3&DiseaseID=68. Accessed 1/15/2013.
  3. Tariq SH. Polyglandular Deficiency Syndromes. The Merck Manual. November 2009; http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/polyglandular_deficiency_syndromes/polyglandular_deficiency_syndromes.html. Accessed 1/15/2013.
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