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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Linear and whorled nevoid hypermelanosis


Other Names for this Disease
  • Linear and whorled hypermelanosis
  • LWNH
  • Nevoid hypermelanosis, linear and whorled
  • Reticulate hyperpigmentation of Iijima
  • Zebra-like hyperpigmentation
More Names
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Cause


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What causes linear and whorled nevoid hypermelanosis?

The cause of linear and whorled nevoid hypermelanosis is not currently known. Around 45 cases have been described in the medical literature.[1][2] Nearly all have occurred sporadically, however apparent genetic transmission has been described in two families.[1][2]

Individual cases of linear and whorled nevoid hypermelanosis have occurred in association with an underlying chromosomal abnormality. People with linear and whorled nevoid hypermelanosis who also have a chromosome abnormality are more likely to have extra-skin symptoms which may impact learning, development, and growth.[1]
Last updated: 3/18/2013

References
  1. Mehta V, Vasanth V, Balachandran C, Mathew M. Linear and whorled nevoid hypermelanosis. Int J Dermatol. 2011 Apr;50(4):491-2; http://www.ncbi.nlm.nih.gov/pubmed/21413967. Accessed 3/18/2013.
  2. Metta AK, Ramachandra S, Sadath N, Manupati S. Linear and whorled nevoid hypermelanosis in three successive generations. Indian J Dermatol Venereol Leprol. 2011 May-Jun;77(3):403; http://www.ncbi.nlm.nih.gov/pubmed/21508598. Accessed 3/18/2013.
  3. Maruani A, Khallouf R, Machet MC, Lorette G. Diffuse linear and whorled nevoid hypermelanosis in a newborn. J Pediatr. 2012 Jan;160(1):171; http://www.ncbi.nlm.nih.gov/pubmed/21868034. Accessed 3/18/2013.