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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Linear and whorled nevoid hypermelanosis


Other Names for this Disease

  • Linear and whorled hypermelanosis
  • LWNH
  • Nevoid hypermelanosis, linear and whorled
  • Reticulate hyperpigmentation of Iijima
  • Zebra-like hyperpigmentation
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of linear and whorled nevoid hypermelanosis?

Signs and symptoms of linear and whorled nevoid hypermelanosis include swirling streaks of hyperpigmented (darkened) skin.  The hyperpigmentation may or may not be apparent at birth, but tends to present by infancy or early childhood. Unlike other rare hyperpigmented skin conditions, the hyperpigmentation occurs without inflammation, blisters, or warty lesions. The hyperpigmentation follows the lines of Blashko and may involve part or much of the body (eyes, palms of the hands, soles of the feet, and mucous membranes are usually not affected). The skin symptoms may progress for one to two years before stabilizing. Children with linear and whorled nevoid hypermelanosis often have otherwise normal physical and neurologic development, however individual cases occurring along with neurologic, heart, growth, and skeletal abnormalities have been described.[1]
Last updated: 3/18/2013

The Human Phenotype Ontology provides the following list of signs and symptoms for Linear and whorled nevoid hypermelanosis. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Autosomal dominant inheritance -
Eosinophilia -
Hyperpigmented streaks -
Infantile onset -

Last updated: 12/1/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Mehta V, Vasanth V, Balachandran C, Mathew M. Linear and whorled nevoid hypermelanosis. Int J Dermatol. 2011 Apr;50(4):491-2; http://www.ncbi.nlm.nih.gov/pubmed/21413967. Accessed 3/18/2013.


Other Names for this Disease
  • Linear and whorled hypermelanosis
  • LWNH
  • Nevoid hypermelanosis, linear and whorled
  • Reticulate hyperpigmentation of Iijima
  • Zebra-like hyperpigmentation
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.