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Multifocal motor neuropathy

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Multifocal motor neuropathy is a progressive muscle disorder that primarily affects the upper limbs, however the lower limbs can also be affected. Signs and symptoms include weakness in the hands and lower arms, and less often (and typically less severe) weakness in the lower limbs. People with this neuropathy may experience cramping, involuntary contractions or twitching, and wasting of affected muscles. It is typical for there to be differences from one side of the body to the other in the specific muscles involved.[1] Multifocal motor neuropathy is caused by abnormal activity of the body's immune system. While there is currently no cure for multifocal motor neuropathy, symptoms tend to be greatly improved with regular/periodic immunoglobulin therapy.[2]
Last updated: 5/1/2013


  1. NINDS Multifocal Motor Neuropathy Information Page. National Institute of Neurological Disorders and Stroke. Accessed 5/1/2013.
  2. Guimarães-Costa R, Bombelli F, Léger JM. Multifocal motor neuropathy. Presse Med. 2013 Apr 24; Accessed 5/1/2013.
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