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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Multifocal motor neuropathy


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Cause


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What causes multifocal motor neuropathy?

Multifocal motor neuropathy is caused by abnormal activity of the body's immune system.[1] Most people with this neuropathy have detectable autoantibodies. Autoantibodies are antibodies that mistakenly target and damage specific tissues or organs of the body.[2] One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between "self" and "non-self" proteins.[2] The most common autoantibody detected in people with multifocal motor neuropathy is anti-GM1 IgM.[1]
Last updated: 5/1/2013

References
  1. Guimarães-Costa R, Bombelli F, Léger JM. Multifocal motor neuropathy. Presse Med. 2013 Apr 24; http://www.ncbi.nlm.nih.gov/pubmed/?term=23623583. Accessed 5/1/2013.
  2. American Association for Clinical Chemistry. Autoantibodies. LabTestsOnline. January 12, 2012; http://labtestsonline.org/understanding/analytes/autoantibodies/. Accessed 5/1/2013.