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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Juvenile amyotrophic lateral sclerosis


Other Names for this Disease
  • Amyotrophic lateral sclerosis, juvenile
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Symptoms


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What are the signs and symptoms of juvenile amyotrophic lateral sclerosis?

Signs and symptoms of juvenile ALS vary but include slowly to very slowly progressive muscle weakness, increased muscle tone, Babinski reflex, muscle spasm (clonus), exaggerated reflexes, muscle wasting, and muscle twitching. Juvenile ALS usually does not affect thinking or mental processing, nor does it tend to cause sensory dysfunction (e.g., numbness or tingling). As the condition progresses muscle involvement can be severe. Some people with juvenile ALS, eventually experience muscle weakness in the face and throat. Some have experienced emotional liability (involuntary crying or laughing) and/or respiratory weakness.[133][1][2]
Last updated: 7/8/2013

References
  1. Orban P, Devon RS, Hayden MR, Leavitt BR. Juvenile Amyotrophic Lateral Sclerosis. Handbook of Clinical Neurology. . 2007;82(3):301-312; http://www.ncbi.nlm.nih.gov/pubmed/18808900. Accessed 7/8/2013.
  2. Rabin BA, Griffin JW, Crain BJ, Scavina M, Chance PF, Cornblath DR. Brain . Autosomal dominant juvenile amyotrophic lateral sclerosis. Brain. 1999;122(8):1539-1550; http://brain.oxfordjournals.org/content/122/8/1539.long. Accessed 7/5/2013.
  3. Donkervoort S, Siddique T. Amyotrophic Lateral Sclerosis. GeneReviews . 2009; http://www.ncbi.nlm.nih.gov/books/NBK1450/. Accessed 4/12/2011.