Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Juvenile amyotrophic lateral sclerosis

Other Names for this Disease
  • Amyotrophic lateral sclerosis, juvenile
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What are the signs and symptoms of juvenile amyotrophic lateral sclerosis?

Signs and symptoms of juvenile ALS vary but include slowly to very slowly progressive muscle weakness, increased muscle tone, Babinski reflex, muscle spasm (clonus), exaggerated reflexes, muscle wasting, and muscle twitching. Juvenile ALS usually does not affect thinking or mental processing, nor does it tend to cause sensory dysfunction (e.g., numbness or tingling). As the condition progresses muscle involvement can be severe. Some people with juvenile ALS, eventually experience muscle weakness in the face and throat. Some have experienced emotional liability (involuntary crying or laughing) and/or respiratory weakness.[133][1][2]
Last updated: 7/8/2013

  1. Orban P, Devon RS, Hayden MR, Leavitt BR. Juvenile Amyotrophic Lateral Sclerosis. Handbook of Clinical Neurology. . 2007;82(3):301-312; Accessed 7/8/2013.
  2. Rabin BA, Griffin JW, Crain BJ, Scavina M, Chance PF, Cornblath DR. Brain . Autosomal dominant juvenile amyotrophic lateral sclerosis. Brain. 1999;122(8):1539-1550; Accessed 7/5/2013.
  3. Donkervoort S, Siddique T. Amyotrophic Lateral Sclerosis. GeneReviews . 2009; Accessed 4/12/2011.