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Primary sclerosing cholangitis
Other Names for this Disease
- Cholangitis, primary sclerosing
- Sclerosing cholangitis
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 Early signs and symptoms include extreme tiredness, abdominal pain, and itchiness. As the condition worsens it may cause jaundice, an enlarged spleen, and eventually liver cirrhosis and failure. Other complications may include weight loss, vitamin deficiency, and osteoporosis. Many people with PSC develop other autoimmune conditions such as inflammatory bowel disease, type 1 diabetes, celiac disease, or thyroid disease. PSC is also a risk factor for cancer of the bile ducts (cholangiocarcinoma).Primary sclerosing cholangitis (PSC) is characterized by inflammation in the bile ducts (cholangitis) that leads to scarring (sclerosis), narrowing of the ducts, and a buildup of bile in the liver.
Last updated: 3/4/2013
- Primary sclerosing cholangitis. Genetic Home Reference. May 2012; http://ghr.nlm.nih.gov/condition/primary-sclerosing-cholangitis. Accessed 3/4/2013.
- Genetics Home Reference (GHR) contains information on Primary sclerosing cholangitis. This website is maintained by the National Library of Medicine.
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- The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.
- The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
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