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Genetic and Rare Diseases Information Center (GARD)

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Chronic Infantile Neurological Cutaneous Articular syndrome


Other Names for this Disease

  • CINCA
  • CINCA syndrome
  • Infantile Onset Multisystem Inflammatory Disease
  • IOMID
  • Multisystem inflammatory disease, neonatal-onset
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

Are any of the symptoms of chronic infantile neurologic cutaneous and articular (CINCA) syndrome (rashes, fevers) contagious?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is chronic infantile neurologic cutaneous and articular (CINCA) syndrome?

Chronic infantile neurologic cutaneous and articular (CINCA) syndrome, also known as 'neonatal onset multisystem inflammatory disease,' or NOMID, is a congenital inflammatory disorder characterized by a triad of neonatal onset of cutaneous symptoms (skin rash), chronic meningitis, and joint pain with recurrent fever and inflammation.[1] CINCA is the most severe form of the cryopyrin associated periodic syndromes (CAPS) caused by mutations in the CIAS1/NLRP3 gene. About 50% of affected individuals have mutations in this gene. This condition is inherited in an autosomal dominant fashion.[2][3]
Last updated: 7/15/2009

What symptoms are associated with chronic infantile neurologic cutaneous and articular (CINCA) syndrome?

The symptoms of CINCA syndrome start at birth, or are observed within the first weeks of life. The first symptoms are usually a skin rash and fever. Infants may also have neurologic symptoms, such as chronic meningitis (inflammation of the membranes surrounding the brain), hearing and vision loss. About 50% of the children later develop severe joint involvement and have significant growth abnormalities.[3] 
Last updated: 7/15/2009

What causes chronic infantile neurologic cutaneous and articular (CINCA) syndrome?

CINCA syndrome is a genetic disease. The disease is inherited as an autosomal dominant disease. That means that either one of the parents is ill with a variant of the disease or that the gene defect was newly formed in the sick child (de novo mutation). A genetic defect is found in only 50% of patients. The gene defect is in a protein called cryopyrin, which has the important task of controlling inflammation in the body.[3] 
Last updated: 7/15/2009

Are any of the symptoms of chronic infantile neurologic cutaneous and articular (CINCA) syndrome contagious?

No, the symptoms of CINCA syndrome are not contagious.[3][4] 
Last updated: 7/15/2009

References
Other Names for this Disease
  • CINCA
  • CINCA syndrome
  • Infantile Onset Multisystem Inflammatory Disease
  • IOMID
  • Multisystem inflammatory disease, neonatal-onset
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.