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Other Names for this Disease
- Juvenile onset macular degeneration
- Stargardt macular dystrophy
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macula, an area of the retina responsible for sharp central vision (needed for detailed tasks such as reading, driving, and recognizing faces). Individuals with the condition have abnormal accumulation of a fatty yellow pigment (lipofuscin) in the cells underlying the macula, which causes central vision loss. People with Stargardt disease also have problems with night vision and some people may have problems with color vision. The signs and symptoms of Stargardt disease typically appear in late childhood to early adulthood and worsen over time. It is usually caused by mutations in the ABCA4 gene and inherited in an autosomal recessive manner, but it can also be caused by mutations in the ELOVL4 gene and inherited in an autosomal dominant manner.Stargardt disease is a genetic eye disorder that causes progressive vision loss. This disorder affects the
Last updated: 2/26/2011
- Stargardt macular degeneration. Genetics Home Reference. November 2010; http://ghr.nlm.nih.gov/condition/stargardt-macular-degeneration. Accessed 2/25/2011.
- The American Society of Gene & Cell Therapy provides information on the treatment of genetic eye diseases.
- Genetics Home Reference (GHR) contains information on Stargardt disease. This website is maintained by the National Library of Medicine.
- The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic.
In Depth Information
- The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Stargardt disease. Click on the link to view a sample search on this topic.