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Transient neonatal diabetes mellitus

Other Names for this Disease
  • Chromosome 6-associated transient diabetes mellitus
  • Diabetes mellitus, 6q24-related transient neonatal
  • Diabetes mellitus, transient neonatal
  • DMTN
  • TNDM
More Names
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Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood.[1] Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy.[2] Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24.[3][4] These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited.[4] Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes.[3] Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.[3]
Last updated: 8/28/2012


  1. Michel Polak. Neonatal diabetes mellitus. Orphanet. March 2007; Accessed 8/24/2012.
  2. Permanent neonatal diabetes mellitus. Genetics Home Reference. July 2011; Accessed 8/24/2012.
  3. Isabel Karen Temple and Deborah JG Mackay. Diabetes Mellitus, 6q24-Related Transient Neonatal. GeneReviews. December 23, 2010; Accessed 8/24/2012.
  4. 6q24-related transient neonatal diabetes mellitus. Genetics Home Reference. February 2011; Accessed 8/28/2012.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Transient neonatal diabetes mellitus. This website is maintained by the National Library of Medicine.
  • The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.

In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Transient neonatal diabetes mellitus. Click on the link to view a sample search on this topic.
  • The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss the different types of transient neonatal diabetes mellitus. Click on the links below to go to OMIM and review these resources.
    Transient neonatal diabetes mellitus 1
    Transient neonatal diabetes mellitus 2
    Transient neonatal diabetes mellitus 3