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Genetic and Rare Diseases Information Center (GARD)

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FACES syndrome

Other Names for this Disease
  • Facial features (unique), anorexia, cachexia, eye and skin anomalies
  • Friedman-Goodman syndrome
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What are signs and symptoms of FACES syndrome?

FACES syndrome affects various parts of the body.  Facial characteristics of FACES syndrome may include deep-set eyes with mild eyelid drooping (ptosis), fat deposits around the eye (xanthelasma), and a nose with a central groove at the tip.[1]

Individuals with FACES syndrome are extremely thin (cachexia) with severe wasting of their muscles.  In addition, their skin may be affected with freckle-like spots (lentigines) and light brown cafe-au-lait spots. Individuals with FACES syndrome can have bowed legs (genu varum), flat feet (pes planus) and mild webbing of fingers and toes (syndactyly).  Other reported features include nasal speech, vision loss due to retinitis pigmentosa, thyroid problems, and a sunken chest bone (pectus excavatum).[1]
Last updated: 7/6/2011

  1. Hennekman R, Krantz I, Allanson J. Gorlin's Syndromes of the Head and Neck. New York, NY: Oxford University Press, Inc; 2010;