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Genetic and Rare Diseases Information Center (GARD)

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Fetal and neonatal alloimmune thrombocytopenia


Other Names for this Disease
  • NAIT
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Overview


Fetal and neonatal alloimmune thrombocytopenia (NAIT) is a condition where a fetus or newborn experiences severe thrombocytopenia (low platelet count). NAIT occurs when the mother's immune system develops antibodies against antigens on the fetal platelets, which are inherited from the father and different from those present in the mother. These antibodies cross the placenta and can cause severe thrombocytopenia in the fetus. NAIT has been considered to be the platelet counterpart of Rh Hemolytic Disease of the Newborn (RHD). The incidence has been estimated at 1/800 to 1/1,000 live births. The spectrum of the disease may range from mild thrombocytopenia to life-threatening bleeding.[1]
Last updated: 6/6/2011

References

  1. Kaplan C. Fetal and neonatal alloimmune thrombocytopenia. Orphanet. October 2006; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=853&lng=EN. Accessed 6/6/2011.
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In Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fetal and neonatal alloimmune thrombocytopenia. Click on the link to view a sample search on this topic.