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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Gordon syndrome


Other Names for this Disease

  • Arthrogryposis distal type 3
  • Arthrogryposis multiplex congenita distal type 2a
  • Camptodactyly, cleft palate, and clubfoot
  • DA3
  • Distal arthrogryposis type 3
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Symptoms

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What are the signs and symptoms of Gordon syndrome?

Gordon syndrome belongs to a group of conditions known as the distal arthrogryposes, which are characterized by stiffness and impaired mobility of certain joints of the lower arms and legs including the wrists, elbows, knees and/or ankles. The range and severity of features in affected individuals can vary. Most infants with Gordon syndrome have several fingers that are permanently fixed in a flexed position (camptodactyly), which may result in limited range of motion and compromised manual dexterity. Affected infants may also have clubfoot. Approximately 20-30% have cleft palate (incomplete closure of the roof of the mouth).[1]

Other signs and symptoms in some individuals may include a bifid uvula (abnormal splitting of the soft hanging tissue at the back of the throat); short stature; dislocation of the hip; abnormal backward curvature of the upper spine (lordosis); and/or kyphoscoliosis. In addition, some affected individuals may have drooping of the eyelids (ptosis); epicanthal folds; syndactyly (webbing of the fingers and/or toes); abnormal skin patterns on the hands and feet (dermatoglyphics); and/or a short, webbed neck (pterygium colli). Some affected males have undescended testes (cryptorchidism). Cognitive development is typically normal.[1]
Last updated: 12/3/2012

References
  1. Gordon syndrome. NORD. March 28, 2008; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/507/viewAbstract. Accessed 12/3/2012.


Other Names for this Disease
  • Arthrogryposis distal type 3
  • Arthrogryposis multiplex congenita distal type 2a
  • Camptodactyly, cleft palate, and clubfoot
  • DA3
  • Distal arthrogryposis type 3
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.