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Genetic and Rare Diseases Information Center (GARD)

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Hyper-IgD syndrome

Other Names for this Disease
  • Hyper IgD syndrome
  • Hyperimmunoglobulinemia D and periodic fever syndrome
  • Periodic fever Dutch type
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Is hyper IgD syndrome inherited?

Hyper IgD syndrome is inherited in an autosomal recessive manner, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.[1][2] About one half of patients have a positive family history.[3]
Last updated: 3/5/2013

  1. Hyper IgD Syndrome. National Organization for Rare Disorders (NORD). 2006; Accessed 3/5/2013.
  2. Frenkel J, Simon A. Hyperimmunoglobulinemia D with recurrent fever. Orphanet. 2011; Accessed 3/5/2013.
  3. Shinawi M, Scaglia F. Hereditary Periodic Fever Syndromes. Medscape Reference. 2013; Accessed 3/5/2013.