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Hypereosinophilic syndrome

Other Names for this Disease
  • HES
  • Hypereosinophilic syndrome, idiopathic
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Hypereosinophilic syndrome is a group of rare blood disorders characterized by increased levels of eosinophils (a type of white blood cell that plays a role in the human immune system) persisting for more than six months. The signs and symptoms are due to involvement of several internal organs and there is usually no evidence of parasites, allergy, or other known causes of an elevated eosinophil count. This condition largely occurs in males, typically at middle age. It usually presents with fever, weight loss, fatigue, and rash. An enlarged liver and spleen and liver is often present. The lungs, kidneys, heart, and nervous system can also be affected.[1]
Last updated: 7/11/2011


  1. Hypereosinophilic syndrome . DermNet NZ. June 2011; Accessed 7/11/2011.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • Genetics Home Reference (GHR) contains information on Hypereosinophilic syndrome. This website is maintained by the National Library of Medicine.
  • The Merck Manuals Online Medical Library provides information on this condition. Click on the link to view the information.

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss idiopathic hypereosinophilic syndrome and familial eosinophilia. Click on the links to go to OMIM and review these resources.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hypereosinophilic syndrome. Click on the link to view a sample search on this topic.