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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Achondrogenesis


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Inheritance

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How is achondrogenesis inherited?

Achondrogenesis type 1A and type 1B are believed to be inherited in an autosomal recessive pattern.  Autosomal recessive inheritance means both copies of the gene in each cell have mutations.  Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but do not show signs and symptoms of the condition.

Achondrogenesis type 2 is considered an autosomal dominant disorder because one copy of the altered gene in each cell is sufficient to cause the condition. It is almost always caused by new (de novo) mutations and typically occurs in people with no history of the disorder in their family.[1]
Last updated: 10/29/2010

References
  1. Achondrogenesis. Genetics Home Reference. February, 2008; http://ghr.nlm.nih.gov/condition/achondrogenesis. Accessed 10/25/2010.


See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.