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Genetic and Rare Diseases Information Center (GARD)

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Tylosis with esophageal cancer

Other Names for this Disease
  • Howel-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • TOC
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What causes Tylosis with esophageal cancer?

Mutations in the RHBDF2 gene have been shown to cause the development of this condition. [1][2][3]
Last updated: 1/18/2013

  1. Tylosis with esophageal cancer. OMIM Database. July 10, 2009; Accessed 4/6/2010.
  2. Saarinen S, Vahteristo P, Lehtonen R, Aittomäki K, Launonen V, Kiviluoto T, Aaltonen LA.. Fam Cancer. 2012 Sep;11; Accessed 1/18/2013.
  3. Blaydon DC, Etheridge SL, Risk JM, Hennies HC, Gay LJ, Carroll R, Plagnol V, McRonald FE, Stevens HP, Spurr NK, Bishop DT, Ellis A, Jankowski J, Field JK, Leigh IM, South AP, Kelsell DP.. Am J Hum Genet. 2012 Feb 10; Accessed 1/18/2013.