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Genetic and Rare Diseases Information Center (GARD)

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Tylosis with esophageal cancer

Other Names for this Disease
  • Howel-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • TOC
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How is Tylosis with esophageal cancer inherited?

This condition has an autosomal dominant pattern of inheritance, which means that a mutation in one copy of the altered gene in each cell is sufficient to cause the disorder.[1] Affected individuals typically have one parent with the condition.
Last updated: 1/18/2013

  1. Spitz JL. Genodermatoses: A clinical guide to genetic skin disorders. Philadelphia: Lippincott Williams & WIlkins; 2005;