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Genetic and Rare Diseases Information Center (GARD)

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Keratosis palmoplantaris papulosa

Other Names for this Disease
  • Buschke fischer brauer syndrome
  • Keratoderma, palmoplantar punctate type 1
  • Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
  • Type I punctate palmoplantar keratoderma
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Your Question

I have keratosis palmoplantaris papulosa and so did my mother. Lately I have been burning off the little nodules using liquid nitrogen. Painful but it does work. Although the condition is genetic, I have been suspicious that there may be a possible exogenous trigger like a virus. Has any research been done to check whether there is any viral involvement?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is there evidence that an exogenous trigger can cause symptoms of keratosis palmoplantaris papulosa (KPPP)?

We are unaware of evidence that exogenous triggers can cause KPPP specifically; however, it is known that some forms of palmoplantar keratoderma (PPK) are acquired as opposed to inherited. Acquired PPKs generally tend to be attributable to underlying causes, including triggers such as certain viruses.[1] Types of acquired PPK that have been recognized include:[1]
  • idiopathic (unknown cause)
  • keratoderma climactericum (occurring more commonly in obese post-menopausal women)
  • drug-related
  • malnutrition-associated
  • chemically induced (e.g. from arsenic)
  • systemic disease-related (including conditions such as hypothyroidism, myxedema, and circulatory disorders)
  • malignancy-associated
  • dermatoses-related (including conditions such as psoriases, lupus, and others)
  • infectious PPK (including human papilloma virus, syphilis, encrusted scabies, leprosy, and tuberculosis)
It is also known that symptoms in individuals with KPPP may be aggravated by exogenous factors including manual work or injury.[2]
Last updated: 11/13/2012

  • Patel S, Zirwas M, English JC 3rd. Acquired palmoplantar keratoderma. Am J Clin Dermatol. 2007; 8(1):1-11.
  • Oztas P et al.,. Punctate palmoplantar keratoderma (Brauer-Buschke-Fisher Syndrome). Am J Clin Dermatol. 2007;