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Keratosis palmoplantaris papulosa
Other Names for this Disease
- Buschke fischer brauer syndrome
- Keratoderma, palmoplantar punctate type 1
- Keratodermia palmoplantaris papulosa, Buschke-Fischer-Brauer type
- Type I punctate palmoplantar keratoderma
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Your QuestionI have keratosis palmoplantaris papulosa and so did my mother. Lately I have been burning off the little nodules using liquid nitrogen. Painful but it does work. Although the condition is genetic, I have been suspicious that there may be a possible exogenous trigger like a virus. Has any research been done to check whether there is any viral involvement?
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We are unaware of evidence that exogenous triggers can cause KPPP specifically; however, it is known that some forms of palmoplantar keratoderma (PPK) are acquired as opposed to inherited. Acquired PPKs generally tend to be attributable to underlying causes, including triggers such as certain viruses. Types of acquired PPK that have been recognized include:
- idiopathic (unknown cause)
- keratoderma climactericum (occurring more commonly in obese post-menopausal women)
- chemically induced (e.g. from arsenic)
- systemic disease-related (including conditions such as hypothyroidism, myxedema, and circulatory disorders)
- dermatoses-related (including conditions such as psoriases, lupus, and others)
- infectious PPK (including human papilloma virus, syphilis, encrusted scabies, leprosy, and tuberculosis)
Last updated: 11/13/2012