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Diseases

Genetic and Rare Diseases Information Center (GARD)

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KID syndrome


Other Names for this Disease
  • Keratitis, Ichthyosis, and Deafness (KID) Syndrome
  • Keratitis-ichthyosis-deafness syndrome, autosomal dominant
  • KID syndrome, autosomal dominant
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Symptoms


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What are the signs and symptoms of KID syndrome?

KID syndrome is present at birth. Nearly all cases have skin involvement, which includes red, rough, thickened plaques that are sometimes scaling, as well as sensorineural deafness or severe hearing impairment. Most affected individuals develop eye problems, usually keratitis (cornea defects), which can result in the eyes being very sensitive to light, small blood vessels growing from the iris over the cornea (neovascularization), and progressive vision loss. A small percentage of people may have recurrent or chronic inflammation of the mucous membrane of the eye (conjunctivitis).[1]

Sparse hair or areas of baldness (alopecia) is relatively common, while a complete lack of hair is rare. The palms of the hands and soles of the feet typically have thickened, hardened skin. Less common is absent or abnormal nails. Other associated symptoms may include recurrent infections, abnormal teeth, reduced sweating,. Some of the rare features include an increased risk for developing squamous cell carcinoma of the skin or mucous membranes and life-threatening infections during the newborn period.[1]
Last updated: 9/9/2011

References
  1. Keratitis Ichthyosis Deafness Syndrome. National Organization for Rare Disorders (NORD). 2006; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/884/viewAbstract. Accessed 9/9/2011.