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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Laryngeal cleft


Other Names for this Disease

  • Anterior submucous laryngeal cleft (subtype)
  • Cleft, larynx posterior
  • Congenital laryngeal clefts (subtype)
  • Posterior laryngeal cleft (PLC)
  • Type 1A (minor laryngeal cleft)
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Overview

laryngeal cleft is a rare abnormality of the separation between the larynx, or voice box, and the esophagus.[1][2] Normally, when the larynx develops, it is completely separate from the esophagus so swallowed foods go directly into the stomach. When a laryngeal cleft occurs, there is an opening between the larynx and the esophagus so food and liquid can pass through the larynx into the lungs.[1] There are several different types of laryngeal clefts (Types I through IV), classified based on the extent of the clefting.[3][4]
Last updated: 9/1/2011

References

  1. Laryngeal Cleft. Children's Hospital Boston. http://www.childrenshospital.org/az/Site1137/mainpageS1137P0.html. Accessed 8/30/2011.
  2. Pezzettigotta SM, Leboulanger N, Roger G, Denoyelle F, Garabedian EN. Laryngeal Cleft. Otolaryngol Clin North Am. 2008; 41:913-933. http://www.ncbi.nlm.nih.gov/pubmed/18775342. Accessed 8/30/2011.
  3. Tewfik TL, Karsan N, Laberge JM. Congenital Malformations of the Esophagus. eMedicine. 2010; http://emedicine.medscape.com/article/837879-overview. Accessed 8/30/2011.
  4. Rahbar R, Rouillon I, Roger G, Lin A, Nuss RC, Denoyelle F, McGill TJ, Healy GB, Garabedian EN. The Presentation and Management of Laryngeal Cleft. Archives of Ololaryngology-Head & Neck Surgery. 2006; 132:1335-1341. http://archotol.ama-assn.org/cgi/content/full/132/12/1335. Accessed 8/30/2011.
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In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Laryngeal cleft. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • Anterior submucous laryngeal cleft (subtype)
  • Cleft, larynx posterior
  • Congenital laryngeal clefts (subtype)
  • Posterior laryngeal cleft (PLC)
  • Type 1A (minor laryngeal cleft)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.