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Genetic and Rare Diseases Information Center (GARD)

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Limb-body wall complex


Other Names for this Disease

  • Aplasia of the cord
  • Body stalk anomaly
  • Cyllosomas
  • Limb body wall complex
  • Short umbilical cord syndrome
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Overview

Limb-body wall complex (LBWC) refers to a congenital disorder characterized by very severe limb defects and anterior body wall defects. The complex includes two or three of the following defects: exencephaly or encephalocele with facial clefts (a rare condition in which there are areas of absent bone and sometimes overlying skin that may occur on one or both sides of the face), thoracoschisis (birth defect in which organs in the thoracic area stick out) and/or abdominoschisis (birth defect in which the organs in the abdominal area stick out), and limb defects. Scoliosis and a short umbilical cord are also frequently found. Other findings such as defects of the internal organs (heart, intestines, genitals, or urinary tract) and persistence of the three separate fluid-filled spaces that lie outside the developing embryo (extraembryonic coelom) have been seen in cases of LBWC. The exact cause of the complex has not been determined.[1] 
Last updated: 10/8/2013

References

  1. Heyroth-Griffis CA, Weaver DD, Faught P, Bellus GA, Torres-Martinez W. On the Spectrum of Limb-Body Wall Complex, Exstrophy of the Cloaca, and Urorectal Septum Malformation Sequence. Am. J. Med. Genet. Part A . 2007;
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Other Names for this Disease
  • Aplasia of the cord
  • Body stalk anomaly
  • Cyllosomas
  • Limb body wall complex
  • Short umbilical cord syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.