Other Names for this Disease
- Transient familial hyperbilirubinemia
- Transient familial neonatal hyperbilirubinemia
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Lucey-Driscoll syndrome is caused by high levels of a bilirubin "conjugating enzyme inhibitor” which is a substance that limits the ability of bilirubin to bind to an enzyme. When bilirubin does not bind efficiently, it builds up in the bloodstream. This inhibitor is thought to occur in the blood (serum) of pregnant women, and it likely blocks the enzyme activity necessary for the development of the fetal liver. Familial cases may result from the pregnant woman having a mutation in the uridine diphosphate-glucuronosyltransferase gene(UGT1A1).
Last updated: 11/16/2010
- W.B. Saunders. Hyperbilirubinemia in Term and Near-Term Infants: Etiologies of Hyperbilirubinemia. Medscape. 2004; http://www.medscape.com/viewarticle/497028_3. Accessed 11/8/2010.
- Irwin M. Arias, Sonia Wolfson, Jerold F. Lucey, and R. James McKay, Jr.. Transient Familial Neonatal Hyperbilirubinemia. Journal of Clinical Investigation. September 1965; 44(9):1442-1450.
- Victor A. McKusick, Deborah L. Stone. HYPERBILIRUBINEMIA, TRANSIENT FAMILIAL NEONATAL. OMIM. April 25, 2002; http://www.ncbi.nlm.nih.gov/omim/237900. Accessed 11/8/2010.