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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Hereditary lymphedema type II


Other Names for this Disease

  • Lymphedema hereditary type 2
  • Lymphedema praecox
  • Lymphedema, hereditary, II
  • Lymphedema, late-onset
  • Meige disease
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Symptoms

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What are the signs and symptoms of hereditary lymphedema type II?

Hereditary lymphedema type II is characterized by the abnormal transport of lymph fluid. This causes the lymph fluid to build up, causing swelling (lymphedema). Individuals with hereditary lymphedema type II usually develop swelling in the lower legs and feet during puberty. Some affected individuals develop a non-contagious skin infection called cellulitis, which can further damage the lymphatic vessels (the thin tubes that carry lymph fluid).[1]   
Last updated: 2/9/2012

The Human Phenotype Ontology provides the following list of signs and symptoms for Hereditary lymphedema type II. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Cleft palate 7.5%
Yellow nails 7.5%
Autosomal dominant inheritance -
Hypoplasia of lymphatic vessels -
Predominantly lower limb lymphedema -

Last updated: 12/1/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Meige lymphedema. Genetics Home Reference (GHR). November 2010; http://ghr.nlm.nih.gov/condition/meige-lymphedema. Accessed 2/9/2012.


Other Names for this Disease
  • Lymphedema hereditary type 2
  • Lymphedema praecox
  • Lymphedema, hereditary, II
  • Lymphedema, late-onset
  • Meige disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.