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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Microscopic polyangiitis


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Cause

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What causes microscopic polyangiitis (MPA)?

The cause of MPA is unknown. It is not contagious, does not usually run in families, and is not a form of cancer. The immune system is thought to play a critical role in the development of MPA.  It is thought that the immune system becomes overactive and causes blood vessel and tissue inflammation, which leads to organ damage. It is not known what causes the immune system to become overactive.[1]
Last updated: 8/13/2014

References
  1. Microscopic Polyangiitis. Cleveland Clinic Web site. November 10, 2010; http://my.clevelandclinic.org/disorders/microscopic_polyangiitis/hic_microscopic_polyangitis.aspx. Accessed 8/13/2014.


See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.