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Genetic and Rare Diseases Information Center (GARD)

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Miller-Fisher syndrome


Other Names for this Disease
  • Cranial variant of GBS
  • Cranial variant of Guillain-Barré syndrome
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Overview


Miller-Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller-Fisher syndrome have a unique antibody that characterizes the disorder. Treatment includes intravenous immunoglobulin (IVIg) or plasmapheresis (a procedure in which antibodies are removed from the blood) and supportive care.[1]
Last updated: 10/21/2011

References

  1. NINDS Miller Fisher Syndrome Information Page. NINDS. August 2011; http://www.ninds.nih.gov/disorders/miller_fisher/miller_fisher.htm. Accessed 10/21/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Miller-Fisher syndrome. Click on the link to view a sample search on this topic.