Multiple endocrine neoplasia type 1
- Endocrine adenomatosis multiple
- MEN 1
- Wermer syndrome
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Recommended screening includes specific types of imaging studies every 3-5 years:
- Head magnetic resonance imaging (MRI scan) begining at age 5.
- Abdominal computed tomography (CT scan) or abdominal MRI scan beginning at age 20.
- Prolactin concentrations, which can be used to screen for pituitary tumors, are measured beginning at age 5.
- Calcium concentrations, which can be used to screen for parathyroid tumors, are measured beginning at age 8.
- Gastrin concentrations, which can be used to screen for gastrinomas (a specific type of gastro-entero-pancreatic tract tumor) are measured beginning at age 20.
When a tumor is detected through screening, the best treatment options depend on many factors, including the size, location, and type of tumor; and whether or not the tumor is "functional" (releasing hormones). Many tumors are treated with surgery. If a tumor is functional, removal of the affected endocrine gland often resolves health problems that may be present as a result of elevated hormones. In some cases, functional tumors can be treated with medications that block the function or lower the levels of the overproduced hormone. Chemotherapy or radiation therapy may also be used to to shrink or destroy tumors.
- Pagon RA, Adam MP, Ardinger HH, et al. Multiple Endocrine Neoplasia Type 1. GeneReviews. September 2012; http://www.ncbi.nlm.nih.gov/books/NBK1538/?report=printable.
- Multiple Endocrine Neoplasia, Type 1. NORD. May 2012; http://rarediseases.org/rare-disease-information/rare-diseases/byID/1229/viewFullReport.
- GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions. Click on the link to view the article on this topic.
- ClinicalTrials.gov lists trials that are studying or have studied Multiple endocrine neoplasia type 1. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.