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Genetic and Rare Diseases Information Center (GARD)

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Osteomesopyknosis


Other Names for this Disease

  • Axial osteosclerosis
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Overview

Osteomesopyknosis is a bone disorder characterized by abnormal hardening of bone (osteosclerosis). It is generally limited to the axial spine, pelvis, and proximal part of the long bones, which is what distinguishes this condition from other sclerosing bone disorders. It is usually diagnosed incidentally in young adults complaining of back pain. Osteomesopyknosis is inherited in an autosomal dominant manner but the genetic cause has not yet been identified. It is generally benign and life expectancy is normal.[1]
Last updated: 9/22/2014

References

  1. Yao AL, Camacho PM. Osteomesopyknosis: a case report and review of sclerosing bone disorders. Endocr Pract. June 1, 2014; 20(6):e106-11. Accessed 9/22/2014.
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In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Osteomesopyknosis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Axial osteosclerosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.