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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Maternally inherited diabetes and deafness


Other Names for this Disease

  • Ballinger Wallace syndrome
  • Diabetes and deafness, maternally inherited
  • Diabetes mellitus type II with deafness
  • Diabetes-deafness syndrome, maternally transmitted
  • MIDD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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When do the diabetes and hearing loss associated with MIDD typically develop?

In MIDD, the diabetes and hearing loss usually develop in mid-adulthood, although the age that they occur varies from childhood to late adulthood. Typically, hearing loss occurs before diabetes.[1]
Last updated: 2/20/2014

The Human Phenotype Ontology provides the following list of signs and symptoms for Maternally inherited diabetes and deafness. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormality of the macula 90%
Chorioretinal abnormality 90%
Constipation 90%
Diabetes mellitus 90%
Malabsorption 90%
Abnormality of lipid metabolism 50%
Aplasia/Hypoplasia of the cerebellum 50%
Arrhythmia 50%
Congestive heart failure 50%
Glomerulopathy 50%
Hypertension 50%
Hypertrophic cardiomyopathy 50%
Muscle weakness 50%
Myalgia 50%
Ophthalmoparesis 50%
Proteinuria 50%
Cataract 7.5%
Incoordination 7.5%
Renal insufficiency 7.5%
Retinopathy 7.5%
Visual impairment 7.5%
Cardiomyopathy 5%
Ptosis 5%
Concentric narrowing of visual fields -
Dysarthria -
External ophthalmoplegia -
Hyperglycemia -
Mitochondrial inheritance -
Pigmentary retinal degeneration -
Retinal degeneration -
Seizures -
Type II diabetes mellitus -
Unsteady gait -
Vertigo -

Last updated: 11/3/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Maternally inherited diabetes and deafness. Genetics Home Reference (GHR). October 2012; http://ghr.nlm.nih.gov/condition/maternally-inherited-diabetes-and-deafness. Accessed 2/20/2014.


Other Names for this Disease
  • Ballinger Wallace syndrome
  • Diabetes and deafness, maternally inherited
  • Diabetes mellitus type II with deafness
  • Diabetes-deafness syndrome, maternally transmitted
  • MIDD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.