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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Oslam syndrome


Other Names for this Disease

  • Osteosarcoma, limb anomalies (clinodactyly, absence of digital ray in foot, bilateral radioulnar synostosis) and macrocytosis without anemia
  • Osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow
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Treatment

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Levoleucovorin
Trade Name
(Manufacturer Name)
Fusilev™
(Spectrum Pharmaceuticals, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Levoleucovorin rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Levoleucovorin is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid
More Information about this product Drug Information Portal

Generic Name Leucovorin
Trade Name
(Manufacturer Name)
Leucovorin calcium®
(Bedford Laboratories)
Indication
The FDA has approved this product to be used in this manner.
For rescue use after high dose methotrexate therapy in the treatment of osteosarcoma.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Methotrexate sodium
Trade Name
(Manufacturer Name)
Methotrexate
(Lederle Laboratories)
Indication
The FDA has approved this product to be used in this manner.
For the use of high dose methotrexate with leucovorin rescue in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.
More Information about this product Drug Information Portal
Medline Plus Health Information

Other Names for this Disease
  • Osteosarcoma, limb anomalies (clinodactyly, absence of digital ray in foot, bilateral radioulnar synostosis) and macrocytosis without anemia
  • Osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.