Other Names for this Disease
- Familial osteochondritis dissecans
- Kônig disease
- Limbic encephalitis with caspr2 antibodies
- Osteochondritis dissecans and short stature
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 In most cases, the exact underlying cause is unknown. Rarely, the condition can affect more than one family member (called familial osteochondritis dissecans); in these cases, osteochondritis dissecans is caused by changes (mutations) in the ACAN gene and is inherited in an autosomal dominant manner. Treatment for the condition varies depending on many factors, including the age of the affected person and the severity of the symptoms, but may include rest; casting or splinting; surgery and/or physical therapy.Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. If the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. However, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. Although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years.
Last updated: 2/8/2015
- Osteochondritis dissecans. Mayo Clinic. September 2012; http://www.mayoclinic.org/diseases-conditions/osteochondritis-dissecans/basics/symptoms/con-20024803.
- Osteochondritis Dissecans. American Academy of Orthopaedic Surgeons. March 2012; http://orthoinfo.aaos.org/topic.cfm?topic=A00610.
- Familial osteochondritis dissecans. Genetics Home Reference. October 2012; http://ghr.nlm.nih.gov/condition/familial-osteochondritis-dissecans.
- Grant Cooper, MD. Osteochondritis Dissecans. Medscape Reference. May 2014; http://emedicine.medscape.com/article/1253074-overview#a0112.
- FamilyDoctor.org provides additional information about Osteochondritis dissecans. Click on the link above to access this information.
- Genetics Home Reference (GHR) contains information on Osteochondritis dissecans. This website is maintained by the National Library of Medicine.
- The Mayo Clinic Web site provides further information on Osteochondritis dissecans.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. Click on the link to view this information. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Osteochondritis dissecans. Click on the link to view a sample search on this topic.