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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Amniotic band syndrome


Other Names for this Disease

  • Amniotic bands sequence
  • Congenital constricting bands
  • Familial amniotic bands
  • Streeter anomaly
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Symptoms

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What are the signs and symptoms of amniotic band syndrome?

The symptoms of amniotic band syndrome depend on the severity and location of the constrictions. The mildest constrictions affect only the superficial skin and may not require treatment. Deeper constrictions may block lymphatic vessels, impair blood flow, and require immediate surgical care.[1] When the bands affect the limbs, the lower part of the limbs are most often involved, especially the middle, long, and index fingers of the hand. When the feet are involved, the bands most commonly affect the big toe.[1]

Pressure from the bands may result in additional abnormalities, such as underdevelopment of a limb, bone abnormalities, amputations, leg-length discrepancy, and club feet. Constriction bands across the head and face may lead to facial clefts. Severe clefts affecting vital organs are often life-threatening.[1]

Last updated: 11/1/2013

The Human Phenotype Ontology provides the following list of signs and symptoms for Amniotic band syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Amniotic constriction ring 90%
Finger syndactyly 90%
Split hand 90%
Talipes 90%
Aplasia/Hypoplasia of the lungs 50%
Aplasia/Hypoplasia of the radius 50%
Lymphedema 50%
Oligohydramnios 50%
Scoliosis 50%
Abnormal lung lobation -
Abnormality of the rib cage -
Bladder exstrophy -
Cleft eyelid -
Cleft palate -
Cleft upper lip -
Ectopia cordis -
Encephalocele -
Facial cleft -
Gastroschisis -
Hand polydactyly -
Omphalocele -
Scoliosis -
Sporadic -
Syndactyly -
Talipes equinovarus -

Last updated: 12/1/2014

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Do T. Streeter Dysplasia. Medscape Reference. February 7, 2012; http://emedicine.medscape.com/article/1260337-overview. Accessed 11/1/2013.


Other Names for this Disease
  • Amniotic bands sequence
  • Congenital constricting bands
  • Familial amniotic bands
  • Streeter anomaly
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.