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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Porokeratosis of Mibelli


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Overview



What is porokeratosis of Mibelli?

How might porokeratosis of Mibelli be treated?


What is porokeratosis of Mibelli?

Porokeratosis of Mibelli is a skin condition that usually develops in children or young adults.  It begins as one or a few small, brownish bumps that grow into raised, bumpy patches.  These patches slowly increase in size over time.  The cause of this condition is unknown, though exposure to sunlight or other forms of radiation, genetic factors and a weakened immune system have been suggested as possible risk factors.  Porokeratosis of Mibelli may sometimes harm normal tissue underlying the affected area; it may also develop into skin cancer.  Treatment depends on the size, location, and aggressiveness of porokeratosis in each affected individual; it may include observation only, medication, or surgery.[1]
Last updated: 8/24/2012

How might porokeratosis of Mibelli be treated?

Treatment depends on the size, location, and aggressiveness of porokeratosis of Mibelli.  Affected individuals are recommended to visit their personal physician regularly to watch for signs of skin cancer, limit sun exposure to the affected area, and use moisturizers as needed.[2]  Imiquimod cream has been found to be an effective treatment, as has 5-fluorouracil cream.  A group of medications called retinoids (including acitretin and isotretinoin), as a pill or cream, may be another treatment option.[2]  If a skin cancer develops from porokeratosis of Mibelli, surgery is recommended.[1]
Last updated: 8/24/2012

References
  1. Spencer LV . Porokeratosis. Medscape Reference. May 30, 2012; http://emedicine.medscape.com/article/1059123-overview#a0101. Accessed 8/21/2012.
  2. Sertznig P, von Felbert V, Megahed M. Porokeratosis: present concepts. Journal of the Academy of Dermatology and Venereology. 2012; 26:404-412. http://www.ncbi.nlm.nih.gov/pubmed/21929548. Accessed 8/16/2012.