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Genetic and Rare Diseases Information Center (GARD)

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Porokeratosis of Mibelli

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How might porokeratosis of Mibelli be treated?

Treatment depends on the size, location, and aggressiveness of porokeratosis of Mibelli.  Affected individuals are recommended to visit their personal physician regularly to watch for signs of skin cancer, limit sun exposure to the affected area, and use moisturizers as needed.[1]  Imiquimod cream has been found to be an effective treatment, as has 5-fluorouracil cream.  A group of medications called retinoids (including acitretin and isotretinoin), as a pill or cream, may be another treatment option.[1]  If a skin cancer develops from porokeratosis of Mibelli, surgery is recommended.[2]
Last updated: 8/24/2012

  1. Sertznig P, von Felbert V, Megahed M. Porokeratosis: present concepts. Journal of the Academy of Dermatology and Venereology. 2012; 26:404-412. Accessed 8/16/2012.
  2. Spencer LV . Porokeratosis. Medscape Reference. May 30, 2012; Accessed 8/21/2012.

Clinical Trials & Research for this Disease

  • The Centers for Mendelian Genomics program is working to discover the causes of rare genetic disorders. For more information about applying to the research study, please visit their website.
  • lists trials that are studying or have studied Porokeratosis of Mibelli. Click on the link to go to to read descriptions of these studies.