Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.


Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Protein C deficiency


* Not a rare disease
Other Names for this Disease
  • Hereditary thrombophilia due to protein C deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.


Newline Maker

What causes protein C deficiency?

Protein C deficiency can be either inherited or acquired. Acquired protein C deficiency may be caused by large blood clots, liver disease, disseminated intravascular coagulation (DIC), infection (sepsis), and vitamin K deficiency. Treatment with warfarin or certain types of chemotherapy can also cause acquired protein C deficiency.[1]

Hereditary protein C deficiency is caused by mutations in the gene that provides instructions for making protein C, called the PROC gene. These mutations disrupt the protein's ability to control blood clotting. If protein C cannot control blood clotting, abnormal blood clots may form.[2]
Last updated: 9/20/2011

  1. Cuker A, Pollak ES. Protein C Deficiency. eMedicine Journal. August 2011; Accessed 9/20/2011.
  2. Protein C deficiency. Genetics Home Reference. October 2009; Accessed 9/20/2011.