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Corticobasal degeneration

Other Names for this Disease
  • CBGD
  • Cortical-Basal Ganglionic degeneration
  • Cortico-Basal Ganglionic Degeneration (CBGD)
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Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.[1]
Last updated: 5/4/2010


  1. NINDS Corticobasal Degeneration Information Page. National Institute of Neurological Disorders and Stroke. 2008; Accessed 5/4/2010.
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Basic Information

  • The University of California San Francisco Web site has an information page on this topic. Click on the link above to view the information page.
  • MedlinePlus provides more information on degenerative nerve diseases in general which you may find helpful. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

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  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Corticobasal degeneration. Click on the link to view a sample search on this topic.