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Thrombotic thrombocytopenic purpura, acquired


Other Names for this Disease

  • Idiopathic thrombotic thrombocytopenic purpura
  • Moschowitz syndrome
  • Purpura, thrombotic thrombocytopenic
  • TTP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Thrombotic thrombocytopenic purpura (TTP), acquired is a blood disorder characterized by low platelets (i.e., thrombocytopenia), small areas of bleeding under the skin (i.e., purpura), low red blood cell count, and hemolytic anemia. TTP causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Resulting complications can include neurological problems (such as personality changes, headaches, confusion, and slurred speech), fever, abnormal kidney function, abdominal pain, and heart problems. Hemolytic anemia can lead to paleness, yellowing of the eyes and skin (jaundice), fatigue, shortness of breath, and a rapid heart rate. TTP, acquired usually appears in late childhood or adulthood. Affected individuals may have a single episode of signs and symptoms, or they may recur over time. This condition results from a reduction in ADAMTS13 enzyme activity caused by autoantibodies.[1]
Last updated: 4/7/2011

References

  1. Thrombotic thrombocytopenic purpura. Genetics Home Reference. 2008; http://ghr.nlm.nih.gov/condition/thrombotic-thrombocytopenic-purpura. Accessed 4/7/2011.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Thrombotic thrombocytopenic purpura, acquired. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it┬áprovides more information about this topic.
  • The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative. Click on the link to view information on┬áthis topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

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Selected Full-Text Journal Articles

Other Names for this Disease
  • Idiopathic thrombotic thrombocytopenic purpura
  • Moschowitz syndrome
  • Purpura, thrombotic thrombocytopenic
  • TTP
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.