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Other Names for this Disease
- Retinoschisis juvenile X chromosome-linked
- Retinoschisis X-linked
- X-linked juvenile retinoschisis
- X-linked retinoschisis
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Your QuestionDoes juvenile retinoschisis cause blindness inevitably? At approximately what age do they go blind?
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People with juvenile retinoschisis begin to experience vision loss during childhood, in some cases as early as 3 months of age. At first, affected males have vision of 20/60 to 20/120. Their vision declines with age, but generally stabilizes after age 20. Visual sharpness remains unchanged in most people until their forties or fifties, when a significant decline in visual acuity typically occurs.
Last updated: 2/23/2010
The effects on vision in juvenile retinoschisis are quite variable. As such, it is difficult to predict how each affect individual's vision will change over time. However, nearly all affected individuals over 70 are legally blind due to the typical progression of this disease. Juvenile retinoschisis may cause other complications that threaten sight at any age, including detachment of the retina (which may occur in up to 22% of individuals with this condition) or bleeding (hemorrhage) into the vitreous gel of the eye (which may affect up to 40%).
Last updated: 2/26/2013
- Sieving PA, MacDonald IM, Meltzer MR, Smaoui N. X-Linked Juvenile Retinoschisis. GeneReviews. May 12, 2009; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=retinoschisis. Accessed 2/23/2010.
- Tantri A, Vrabec TR, Cu-Unjieng A, Frost A, Annesley WH Jr, Donoso LA. X-linked retinoschisis: a clinical and molecular genetic review. Survey of Ophthalmology. 2004; 49:214-230. http://www.ncbi.nlm.nih.gov/pubmed/14998693. Accessed 2/22/2012.