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Multiple endocrine neoplasia type 2A
Other Names for this Disease
- MEN 2A
- MEN-2A syndrome
- Pheochromocytoma and amyloid producing medullary thyroid carcinoma
- PTC syndrome
- Sipple syndrome
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RET gene. Individuals with MEN 2A are at high risk of developing medullary carcinoma of the thyroid. About 50% will develop pheochromocytoma, a tumor of the adrenal glands which may increase blood pressure. Individuals with MEN 2A are also at increased risk for parathyroid adenoma or hyperplasia (overgrowth of the parathyroid gland). Occasionally an itchy skin condition called cutaneous lichen amyloidosis also occurs in people with type 2A disease. The condition is inherited in an autosomal dominant manner.Multiple endocrine neoplasia type 2A (MEN 2A) is is an inherited disorder caused by mutations in the
Last updated: 2/11/2011
- Multiple endocrine neoplasia. Genetics Home Reference (GHR). 2006; http://ghr.nlm.nih.gov/condition/multiple-endocrine-neoplasia. Accessed 2/11/2011.
- Moline J, Eng C. Multiple Endocrine Neoplasia Type 2. GeneReviews. 2010; http://www.ncbi.nlm.nih.gov/books/NBK1257/. Accessed 2/11/2011.
- Daly PA. Multiple Endocrine Neoplasia Syndromes. The Merck Manual of Medical Information, 2nd. Home Edition. 2008; http://www.merckmanuals.com/home/print/sec13/ch167/ch167a.html. Accessed 2/11/2011.
- Genetics Home Reference (GHR) contains information on Multiple endocrine neoplasia type 2A. This website is maintained by the National Library of Medicine.
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- The Online Mendelian Inheritance in Man (OMIM) database contains genetics resources that discuss Multiple endocrine neoplasia type 2A. Click on the link to go to OMIM and review these resources.
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