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Genetic and Rare Diseases Information Center (GARD)

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Infantile-onset ascending hereditary spastic paralysis


Other Names for this Disease

  • IAHSP
  • Spastic paralysis, infantile onset ascending
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Infantile-onset ascending hereditary spastic paralysis is a motor neuron disease characterized by progressive weakness and stiffness of muscles in the arms, legs, and face. Initial symptoms usually occur within the first 2 years of life and include weakness of the legs, leg muscles that are abnormally tight and stiff, and eventual paralysis of the legs. Over time, muscle weakness and stiffness travels up (ascends) the body from the legs to the head. Infantile-onset ascending hereditary spastic paralysisis caused by mutations in the ALS2 gene, and this condition is inherited in an autosomal recessive pattern.[1]
Last updated: 9/1/2009

References

  1. Infantile-onset ascending hereditary spastic paralysis. Genetics Home Reference Website. May 2007; http://ghr.nlm.nih.gov/condition=infantileonsetascendinghereditaryspasticparalysis. Accessed 9/1/2009.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Infantile-onset ascending hereditary spastic paralysis. This website is maintained by the National Library of Medicine.

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Infantile-onset ascending hereditary spastic paralysis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • IAHSP
  • Spastic paralysis, infantile onset ascending
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.