Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Spastic paraplegia 11


Other Names for this Disease

  • Autosomal recessive spastic paraplegia type 11
  • Hereditary spastic paraplegia 11
  • Hereditary spastic paraplegia mental impairment and thin corpus callosum
  • Nakamura Osame syndrome
  • Spastic paraplegia - intellectual deficit - thin corpus callosum
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Spastic paraplegia 11 is a form of hereditary spastic paraplegia. People with spastic paraplegia 11 experience progressive muscle stiffness and eventual paralysis of the lower limbs, as well as a range of other neurologic symptoms.[1] The tissue connecting the left and right halves of the brain (corpus callosum) is abnormally thin in individuals with this condition. Spastic paraplegia 11 is caused by mutations in the SPG11 gene and is passed through families in an autosomal recessive fashion.[2]

Last updated: 4/21/2010

References

  1. Spastic paraplegia 11, autosomal recessive SPG11. Online Mendelian Inheritance in Man. 2010; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604360. Accessed 4/16/2010.
  2. Spastic paraplegia type 11. Genetics Home Reference. 2009; http://www.ghr.nlm.nih.gov/condition=spasticparaplegiatype11. Accessed 4/21/2010.
  3. Stevanin G, Durr A, Brice A. Spastic paraplegia type 11. GeneReviews. 2009; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=spg11. Accessed 4/21/2010.
Your Questions Answered
by the Genetic and Rare Diseases Information Center

1 question(s) from the public on Spastic paraplegia 11 have been answered. See questions and answers. You can also submit a new question.

Basic Information

In Depth Information

  • The Online Mendelian Inheritance in Man (OMIM) is an catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Spastic paraplegia 11. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Autosomal recessive spastic paraplegia type 11
  • Hereditary spastic paraplegia 11
  • Hereditary spastic paraplegia mental impairment and thin corpus callosum
  • Nakamura Osame syndrome
  • Spastic paraplegia - intellectual deficit - thin corpus callosum
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.