Spastic paraplegia 11
Other Names for this Disease
- Autosomal recessive spastic paraplegia type 11
- Hereditary spastic paraplegia 11
- Hereditary spastic paraplegia mental impairment and thin corpus callosum
- Nakamura Osame syndrome
- Nakamura-Osame syndrome
What are the signs and symptoms of spastic paraplegia 11?
Spasticity (progressive muscle stiffness)
Paraplegia (eventual paralysis of the lower limbs)
Numbness, tingling, or pain in the arms and legs
Disturbance in the nerves used for muscle movement
Exaggerated reflexes of the lower limbs
Reduced bladder control
Less common features, include:
Age at time of symptom onset varies from infancy to early adulthood, with onset in infancy to adolescence being most common. Learning disability may begin in childhood. Most people experience a decline in intellectual ability and an increase in muscle weakness and nerve abnormalities over time. As the condition progresses, some people require wheelchair assistance (often 10 to 20 years after symptom onset).
- Spastic paraplegia 11, autosomal recessive SPG11. Online Mendelian Inheritance in Man. 2010; http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604360. Accessed 4/16/2010.
- Spastic paraplegia type 11. Genetics Home Reference. 2009; http://www.ghr.nlm.nih.gov/condition=spasticparaplegiatype11. Accessed 4/21/2010.
- Stevanin G, Durr A, Brice A. Spastic paraplegia type 11. GeneReviews. 2009; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=spg11. Accessed 4/21/2010.