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Fetal retinoid syndrome

Other Names for this Disease
  • Accutane fetal effects of
  • Accutane-exposed pregnancies
  • Acutane embryopathy
  • Isotretinoin (RoAccutane) embryopathy
  • Isotretinoin embryopathy
More Names
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Fetal retinoid syndrome is a characteristic pattern of physical and mental birth defects that results from maternal use of retinoids during pregnancy. The most well known retinoid is isotretinoin (Accutane), a drug used to treat severe cystic acne.[1] Birth defects associated with fetal retinoid syndrome include: hydrocephalus, microcephaly, intellectual disabilities, ear and eye abnormalities, cleft palate and other facial differences, and heart defects.[1][2] Isotretinoin can cause these birth defects in the early weeks of pregnancy, even before a woman knows that she is pregnant.[2]

Last updated: 4/12/2010


  1. Fetal Retinoid Syndrome. National Organization for Rare Disorders (NORD). 2003; Accessed 4/9/2010.
  2. Accutane (Isotretinoin) and Other Retinoids. March of Dimes. 2008; Accessed 4/9/2010.
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Basic Information

  • The March of Dimes provides information about fetal retinoid syndrome. Click on the above link to access this information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Fetal retinoid syndrome. Click on the link to view a sample search on this topic.