Acute promyelocytic leukemia
Other Names for this Disease
- Acute myeloblastic leukemia type 3
- Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
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Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
Last updated: 6/23/2011
Acute promyelocytic leukemia accounts for 5-15% of all adult leukemias. There are approximately 30,800 cases of acute leukemia diagnosed yearly; about 1000 of these are acute promyelocytic leukemia.
Last updated: 11/18/2009
- General Information About Adult Myeloid Leukemia. National Cancer Institute (NCI). 2009; http://www.cancer.gov/cancertopics/pdq/treatment/adultAML/Patient#Keypoint2. Accessed 6/23/2011.
- Acute promyelocytic leukemia. Genetics Home Reference (GHR). April 2011; http://ghr.nlm.nih.gov/condition/acute-promyelocytic-leukemia. Accessed 6/23/2011.
- Kotiah SD, Besa EC. Acute Promyelocytic Leukemia. eMedicine. 2009; http://emedicine.medscape.com/article/1495306-overview. Accessed 11/18/2009.