- Autophagic vacuolar myopathy
Your QuestionI have recently been diagnosed with vacuolar myopathy and wish to know more about what it is and how it can effect health. My main difficulty is with stairs. I have been told this condition can affect my whole body and am concerned about my heart muscle.
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The effect of vacuolar myopathy on the heart depends on the specific type of vacuolar myopathy. The heart can be severely affected by growing too large (cardiomyopathy) or not beating regularly (arrhythmia). This may occur in Danon disease and adult-onset autophagic vacuolar myopathy with multiorgan involvement, which are two types of vacuolar myopathy. The symptoms of the heart being affected include general weakness and difficulty breathing.
In another type of vacuolar myopathy known as acid maltase deficiency, the heart is less commonly affected. And in yet another type, x-linked myopathy with excessive autophagy, the heart is not affected at all.
- Nishino I. Autophagic vacuolar myopathy. Seminars in Pediatric Neurology. 2006; 13:90-95. http://www.ncbi.nlm.nih.gov/pubmed/17027858. Accessed 6/26/2012.