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Genetic and Rare Diseases Information Center (GARD)

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Inflammatory linear verrucous epidermal nevus

Other Names for this Disease
  • Inflammatory linear verrucous epidermal naevus
  • Inflammatory linear verrucous epidermal nevus
  • Linear verrucose epidermal nevus
  • Verrucous epidermal nevus
More Names
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Your Question

Is this is a genetic disease and can it be transmitted from a mother to her baby?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is inflammatory linear verrucous epidermal nevus?

Inflammatory linear verrucous epidermal nevus (ILVEN) is a type of skin overgrowth. The skin nevi appear as skin colored, brown, or reddish, wort-like papules. The nevi join to form well-demarcated plaques. The plaques may be itchy and often affects only one side of the body.[1] ILVEN tends to be present from birth to early childhood. It affects females more often than males. It usually occurs alone. Rarely ILVEN occurs in association with epidermal nevus syndrome. While rare ILVEN may become cancerous (i.e., transform to basal cell or squamous cell carcinoma).[2] The cause of ILVEN is currently unknown.[1][3][2][4] Click here to visit the DermNetNZ Web site and view an image of ILVEN.
Last updated: 6/10/2011

Is inflammatory linear verrucous epidermal nevus (ILVEN) genetic? Can a mother with ILVEN pass this condition to her child?

Most often inflammatory linear verrucous epidermal nevus (ILVEN) occurs sporadically for the first time in a family in the affected individual. It is likely due to a random gene mutation that occurred in the individual's skin cells while he/she was developing in his/her mother's womb. Future offspring and other family members are usually not affected, however there have been rare reports of ILVEN occurring in more than one member of the same family.[2] 

Insuring an accurate diagnosis is important in determining your risk to future offspring. There is a rare skin condition called epidermolytic epidermal naevus, where a parent with epidermal nevi, has gone on to have a child with more extensive or generalized disease.[5] We are not aware of a similar case report for individuals with ILVEN. Certain epidermal nevus syndromes may also be associated with an increased risk to offspring. To learn more about your specific risk to future offspring, we recommend that you consult with a genetics professional. Genetics clinics are a source of information for individuals and families regarding diagnosis, treatment, inheritance, and genetic risks to other family members. More information about genetic consultations is available from Genetics Home Reference at To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral.

The following online resources can help you find a genetics professional in your community:  

Last updated: 3/23/2011