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Diseases

Genetic and Rare Diseases Information Center (GARD)

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VLCAD deficiency


Other Names for this Disease
  • Very long-chain acyl-CoA dehydrogenase deficiency
  • VLCADD
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Inheritance


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How is VLCAD deficiency inherited?

VLCAD deficiency is inherited in an autosomal recessive manner. This means that both copies of the disease-causing gene (one inherited from each parent) must have a mutation in order to cause signs and symptoms of the condition. An individual who has one mutated copy of the gene and one normal copy is referred to as a carrier. Carriers usually do not have signs or symptoms of the condition. When two carrier parents have children, each child has a 25% (1 in 4) risk to be affected, a 50% (1 in 2) risk to be a carrier like each parent, and a 25% risk to be unaffected and not a carrier.
Last updated: 12/10/2013